Manager of the LCSB Disease Modelling and Screening Platform

About the LCSB

The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character.

The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg.
We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in Alzheimer's and Parkinson's disease and their contributing factors. The LCSB recruits talented scientists from various disciplines: computer scientists, mathematicians, biologists, chemists, engineers, physicists and clinicians from more than 50 countries currently work at the LCSB. We excel because we are truly interdisciplinary, and together we contribute to science and society.

The Disease Modelling & Screening Platform (DMSP) is a dynamic scientific service provider, operating under the joint auspices of the LCSB and the Luxembourg Institute of Health (LIH). It is dedicated to advancing translational research projects at the LCSB and LIH, as well as for external clients.

At DMSP, we are committed to advancing early drug discovery through the implementation of cell and organoid-based phenotypic screening. Our primary goal is to support research teams within the LCSB and LIH, as well as academic and commercial partners both in Luxembourg and abroad. Our overarching vision is to provide access to state-of-the-art infrastructure, complemented by expert guidance in experimental design, model selection, compound delivery, and the development and execution of high-content analysis.

The successful candidate will work under the supervision of the Scientific Platform Coordinator, as part of LCSB`s Scientific Platforms, in close alignment with the DMSP Steering Committee and the LCSB Director.

Your role

The Manager of the Disease Modelling & Screening Platform (DMSP) will lead activities in developing visual assays for high-content screening (HCS) and oversee collaborative drug discovery research projects, guiding a team of 2-3 research support engineers and technicians.

Core Responsibilities:

• Experiment Design and Execution: Support customers in designing various experiments, including assay development and optimization, integration of 3D cell culture, compound library screening, identification of lead candidates, and CRISPR-Cas9 screening
• Imaging Technology Integration: Adapt and incorporate advanced imaging technologies to analyze complex cell mixtures
• Data Analysis and Reporting: Analyze data and present results in written reports and documentation.
• Instrument Maintenance: Maintain and troubleshoot analytical instruments as needed
• Innovative Approaches: Explore and implement innovative methodologies to strengthen the platform's technological foundation, facilitating the development of new methods, publications, and patents
• Strategic and Operational Management: Formulate and execute strategic and operational R&D and business plans to drive platform growth and success
• Financial Oversight: Oversee the operational management of the platform, including cost calculation, pricing, invoicing, and financial oversight
• Fundraising and Partnerships: Seek additional funding by supporting customers in grant writing or establishing partnerships with SMEs and industrial entities
• Steering Committee Reporting: Regularly report to the DMSP Steering Committee, providing strategic guidance for the platform's development
  
  

This role is pivotal in driving innovation and ensuring the successful execution of our high-content screening initiatives. For further information, please contact LCSB`s Scientific Platform Coordinator Jan ROZMAN (). Use the job reference number mentioned above in the subject line of your email.

Your profile

Education:

• PhD degree in Systems Biology, Life Science, Biology, Chemistry/Biochemistry or any other closely related field
  
  

Professional experience:

• At least 5 years of experience in drug discovery principles, miniaturization, automation engineering, and proficiency in imaging and confocal microscopy techniques. Proven track record in translational research, including hands-on experience in assay development and high-content/high-throughput screening
  
  

• Strong interpersonal and stakeholder management skills. Ability to collaborate effectively with cross-functional teams, including project partners from diverse fields such as biology, compound management, AI, bioinformatics, and analytical chemistry. Familiarity with all aspects of high-content screening, including adapting and scaling established assays to the screening platform, 3D cell culture, and the use of organoids
• Exceptional oral and written communication skills in English, with the ability to present technologies and research results effectively in meetings and conferences

We offer

• Multilingual and international character. Modern institution with a personal atmosphere. Staff coming from 90 countries. Member of the "University of the Greater Region" (UniGR)
• A modern and dynamic university. High-quality equipment. Close ties to the business world and to the Luxembourg labour market. A unique urban site with excellent infrastructure
• A partner for society and industry. Cooperation with European institutions, innovative companies, the Financial Centre and with numerous non-academic partners such as ministries, local governments, associations, NGOs …

How to apply

Applications should include:

• A detailed curriculum vitae (CV)
• A cover letter describing your motivation to join our Centre, and what makes your experience and profile the perfect fit for our advertised position as DMSP Manager

Early application is highly encouraged, as the applications will be processed upon reception. Please apply ONLINE formally through the HR system. Applications by Email will not be considered.

All qualified individuals are encouraged to apply. In line with our values, the University of Luxembourg promotes an inclusive culture. We encourage applications from individuals of all backgrounds and are dedicated to upholding equality and respect for our employees and students.

General information:

• Contract Type: Fixed Term Contract 24 Month (extension possible up to 60 months in total)
• Work Hours: Full Time 40.0 Hours per Week
• Location: Campus Belval
• Internal Title: Research scientist
• Job Reference: UOL06998

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